The CC chemokine CCL20 and its receptor CCR6

被引：809

作者：

Schutyser, E ^{[1
]}

Struyf, S ^{[1
]}

Van Damme, J ^{[1
]}

机构：

[1] Rega Inst, Lab Mol Immunol, B-3000 Louvain, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 05期

关键词：

CCL20; CCR6; beta-defensins; rheumatoid arthritis; cancer;

D O I：

10.1016/S1359-6101(03)00049-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-L is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins. The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells (DC), effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis. In this review, the discovery, the gene and protein structure, the in vitro biological activities, the cell and inducer specific expression and the tissue distribution of CCL20 and CCR6 are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：409 / 426

页数：18

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