The amplification of TCR signaling by dynamic membrane microdomains

被引：85

作者：

Viola, A ^{[1
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 06期

关键词：

D O I：

10.1016/S1471-4906(01)01938-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell responses to infectious agents. Recently, many laboratories have suggested that TCR triggering might be compartmentalized in plasma membrane microdomains called rafts. Results on the role of lipid rafts as signaling units in TCR triggering suggest that rafts might be used by T cells to fine-tune their immune responsiveness.

引用

页码：322 / 327

页数：6

共 66 条

[51] JNK IS INVOLVED IN SIGNAL INTEGRATION DURING COSTIMULATION OF T-LYMPHOCYTES [J].

SU, B ;

JACINTO, E ;

HIBI, M ;

KALLUNKI, T ;

KARIN, M ;

BEN-NERIAH, Y .

CELL, 1994, 77 (05) :727-736

[52] The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story [J].

Thomas, ML .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (03) :270-276

[53]

Tuosto L, 1998, EUR J IMMUNOL, V28, P2131, DOI 10.1002/(SICI)1521-4141(199807)28:07<2131::AID-IMMU2131>3.0.CO

[54]

2-Q

[55]

Tuosto L, 2001, EUR J IMMUNOL, V31, P345, DOI 10.1002/1521-4141(200102)31:2<345::AID-IMMU345>3.0.CO

[56]

2-L

[57] GPI-anchored proteins are organized in submicron domains at the cell surface [J].

Varma, R ;

Mayor, S .

NATURE, 1998, 394 (6695) :798-801

[58] Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering [J].

Viola, A ;

Salio, M ;

Tuosto, L ;

Linkert, S ;

Acuto, O ;

Lanzavecchia, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) :1775-1779

[59] T cell activation determined by T cell receptor number and tunable thresholds [J].

Viola, A ;

Lanzavecchia, A .

SCIENCE, 1996, 273 (5271) :104-106

[60] T lymphocyte costimulation mediated by reorganization of membrane microdomains [J].

Viola, A ;

Schroeder, S ;

Sakakibara, Y ;

Lanzavecchia, A .

SCIENCE, 1999, 283 (5402) :680-682

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