Apolipoprotein B:: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis

被引：229

作者：

Olofsson, SO ^{[1
]}

Borèn, J ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Univ Hosp, Wallenberg Lab Cardiovasc Res, SE-41345 Gothenburg, Sweden

来源：

JOURNAL OF INTERNAL MEDICINE | 2005年 / 258卷 / 05期

关键词：

apolipoproteins B; atherosclerosis; proteoglycans; very low-density lipoprotein assembly; very low-density lipoproteins;

D O I：

10.1111/j.1365-2796.2005.01556.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Apolipoprotein (apo) B exists in two forms apoB100 and apoB48. ApoB100 is present on very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and LDL. ApoB100 assembles VLDL particles in the liver. This process starts by the formation of a pre-VLDL, which is retained in the cell unless converted to the triglyceride-poor VLDL2. VLDL2 is secreted or converted to VLDL1 by a bulk lipidation in the Golgi apparatus. ApoB100 has a central role in the development of atherosclerosis. Two proteoglycan-binding sequences in apoB100 have been identified, which are important for retaining the lipoprotein in the intima of the artery. Retention is essential for the development of the atherosclerotic lesion.

引用

页码：395 / 410

页数：16

共 114 条

[31] ER quality control: towards an understanding at the molecular level [J].

Ellgaard, L ;

Helenius, A .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (04) :431-437

[32] Cisternal maturation and vesicle transport: join the band wagon! (Review) [J].

Elsner, M ;

Hashimoto, H ;

Nilsson, T .

MOLECULAR MEMBRANE BIOLOGY, 2003, 20 (03) :221-229

[33] Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins [J].

Fisher, EA ;

Ginsberg, HN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (20) :17377-17380

[34] The triple threat to nascent apolipoprotein B - Evidence for multiple, distinct degradative pathways [J].

Fisher, EA ;

Pan, M ;

Chen, XL ;

Wu, XY ;

Wang, HX ;

Jamil, H ;

Sparks, JD ;

Williams, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (30) :27855-27863

[35] HELSINKI HEART-STUDY - PRIMARY-PREVENTION TRIAL WITH GEMFIBROZIL IN MIDDLE-AGED MEN WITH DYSLIPIDEMIA - SAFETY OF TREATMENT, CHANGES IN RISK-FACTORS, AND INCIDENCE OF CORONARY HEART-DISEASE [J].

FRICK, MH ;

ELO, O ;

HAAPA, K ;

HEINONEN, OP ;

HEINSALMI, P ;

HELO, P ;

HUTTUNEN, JK ;

KAITANIEMI, P ;

KOSKINEN, P ;

MANNINEN, V ;

MAENPAA, H ;

MALKONEN, M ;

MANTTARI, M ;

NOROLA, S ;

PASTERNACK, A ;

PIKKARAINEN, J ;

ROMO, M ;

SJOBLOM, T ;

NIKKILA, EA .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (20) :1237-1245

[36] Synthesis and function of hepatic very-low-density lipoprotein [J].

Gibbons, GF ;

Wiggins, D ;

Brown, AM ;

Hebbachi, AM .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 :59-64

[37] Mobilisation of triacylglycerol stores [J].

Gibbons, GF ;

Islam, K ;

Pease, RJ .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1483 (01) :37-57

[38] Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion [J].

Gilham, D ;

Ho, S ;

Rasouli, M ;

Martres, P ;

Vance, DE ;

Lehner, R .

FASEB JOURNAL, 2003, 17 (10) :1685-+

[39] Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B [J].

Gillian-Daniel, DL ;

Bates, PW ;

Tebon, A ;

Attie, AD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) :4337-4342

[40] Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step [J].

Gordon, DA ;

Jamil, H ;

Gregg, RE ;

Olofsson, SO ;

Boren, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (51) :33047-33053

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