The Effect of Abnormal Iron Metabolism on Osteoporosis

被引：134

作者：

Che, Jingmin ^{[1
,2
,3
]}

Yang, Jiancheng ^{[2
,3
]}

Zhao, Bin ^{[2
,3
]}

Zhang, Ge ^{[4
]}

Wang, Luyao ^{[4
]}

Peng, Songlin ^{[5
]}

Shang, Peng ^{[1
,3
]}

机构：

[1] Northwestern Polytech Univ Shenzhen, Res & Dev Inst, Shenzhen 518057, Guangdong, Peoples R China

[2] Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China

[3] Northwestern Polytech Univ, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China

[4] Hong Kong Baptist Univ, Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong, Peoples R China

[5] Shenzhen Peoples Hosp, Dept Spine Surg, Shenzhen 518000, Guangdong, Peoples R China

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2020年 / 195卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Iron metabolism; Osteoporosis; Iron overload; Iron deficiency; STATIC MAGNETIC-FIELD; BONE LOSS; OXIDATIVE STRESS; IN-VITRO; OSTEOCLAST DIFFERENTIATION; TRANSFERRIN RECEPTOR; MOLECULAR-MECHANISMS; FERROXIDASE ACTIVITY; HEART-FAILURE; MURINE MODEL;

D O I：

10.1007/s12011-019-01867-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Iron is one of the important trace elements in life activities. Abnormal iron metabolism increases the incidence of many skeletal diseases, especially for osteoporosis. Iron metabolism plays a key role in the bone homeostasis. Disturbance of iron metabolism not only promotes osteoclast differentiation and apoptosis of osteoblasts but also inhibits proliferation and differentiation of osteoblasts, which eventually destroys the balance of bone remodeling. The strength and density of bone can be weakened by the disordered iron metabolism, which increases the incidence of osteoporosis. Clinically, compounds or drugs that regulate iron metabolism are used for the treatment of osteoporosis. The goal of this review summarizes the new progress on the effect of iron overload or deficiency on osteoporosis and the mechanism of disordered iron metabolism on osteoporosis. Explaining the relationship of iron metabolism with osteoporosis may provide ideas for clinical treatment and development of new drugs.

引用

页码：353 / 365

页数：13

共 152 条

[91]

A Red Carpet for Iron Metabolism [J].