Metabolomics as a Key Integrator for "Omic" Advancement of Personalized Medicine and Future Therapies

被引：35

作者：

Eckhart, Andrea D. ^{[1
,2
]}

Beebe, Kirk ^{[2
]}

Milburn, Mike ^{[2
]}

机构：

[1] Thomas Jefferson Univ, Ctr Translat Med, Philadelphia, PA 19107 USA

[2] Metabolon Inc, Durham, NC USA

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2012年 / 5卷 / 03期

关键词：

metabolomics; metabolome; genomics; proteomics; personalized medicine; biomarker; GENOME-WIDE ASSOCIATION; BREAST; PATHOPHYSIOLOGY; LOCUS;

D O I：

10.1111/j.1752-8062.2011.00388.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Investigation into biological complexity, whether for a better understanding of disease or drug process, is a monumental task plaguing investigators. The lure of omic technologies for circumventing much of these challenges has led to widespread efforts and adoption. It is becoming clearer that a single omic approach (e.g., genomics) is often insufficient for completely defining the complexity in these biological systems. Hence, there is an increasing awareness that a systems approach will serve to increase resolution and confidence and provide a strong foundation for further hypothesis-driven investigation. Although certain metabolites are already considered clinically important, the profiling of metabolites via metabolomics (the profiling of metabolites to fully characterize metabolic pathways) is the most recent to mature of these omic technologies and has been only recently adopted as compared to genomic or proteomic approaches in systems inquiries. Recent reports suggest that this omic may well be a key data stream in systems investigations for endeavors in personalized medicine and biomarker identification, as it seems most closely relevant to the phenotype. Clin Trans Sci 2012; Volume #: 14

引用

页码：285 / 288

页数：4

共 31 条

[21] The consensus coding sequences of human breast and colorectal cancers [J].

Sjoeblom, Tobias ;

Jones, Sian ;

Wood, Laura D. ;

Parsons, D. Williams ;

Lin, Jimmy ;

Barber, Thomas D. ;

Mandelker, Diana ;

Leary, Rebecca J. ;

Ptak, Janine ;

Silliman, Natalie ;

Szabo, Steve ;

Buckhaults, Phillip ;

Farrell, Christopher ;

Meeh, Paul ;

Markowitz, Sanford D. ;

Willis, Joseph ;

Dawson, Dawn ;

Willson, James K. V. ;

Gazdar, Adi F. ;

Hartigan, James ;

Wu, Leo ;

Liu, Changsheng ;

Parmigiani, Giovanni ;

Park, Ben Ho ;

Bachman, Kurtis E. ;

Papadopoulos, Nickolas ;

Vogelstein, Bert ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. .

SCIENCE, 2006, 314 (5797) :268-274

[22] GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma [J].

Smedby, Karin E. ;

Foo, Jia Nee ;

Skibola, Christine F. ;

Darabi, Hatef ;

Conde, Lucia ;

Hjalgrim, Henrik ;

Kumar, Vikrant ;

Chang, Ellen T. ;

Rothman, Nathaniel ;

Cerhan, James R. ;

Brooks-Wilson, Angela R. ;

Rehnberg, Emil ;

Irwan, Ishak D. ;

Ryder, Lars P. ;

Brown, Peter N. ;

Bracci, Paige M. ;

Agana, Luz ;

Riby, Jacques ;

Cozen, Wendy ;

Davis, Scott ;

Hartge, Patricia ;

Morton, Lindsay M. ;

Severson, Richard K. ;

Wang, Sophia S. ;

Slager, Susan L. ;

Fredericksen, Zachary S. ;

Novak, Anne J. ;

Kay, Neil E. ;

Habermann, Thomas M. ;

Armstrong, Bruce ;

Kricker, Anne ;

Milliken, Sam ;

Purdue, Mark P. ;

Vajdic, Claire M. ;

Boyle, Peter ;

Lan, Qing ;

Zahm, Shelia H. ;

Zhang, Yawei ;

Zheng, Tongzhang ;

Leach, Stephen ;

Spinelli, John J. ;

Smith, Martyn T. ;

Chanock, Stephen J. ;

Padyukov, Leonid ;

Alfredsson, Lars ;

Klareskog, Lars ;

Glimelius, Bengt ;

Melbye, Mads ;

Liu, Edison T. ;

Adami, Hans-Olov .

PLOS GENETICS, 2011, 7 (04)

[23] Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression [J].

Sreekumar, Arun ;

Poisson, Laila M. ;

Rajendiran, Thekkelnaycke M. ;

Khan, Amjad P. ;

Cao, Qi ;

Yu, Jindan ;

Laxman, Bharathi ;

Mehra, Rohit ;

Lonigro, Robert J. ;

Li, Yong ;

Nyati, Mukesh K. ;

Ahsan, Aarif ;

Kalyana-Sundaram, Shanker ;

Han, Bo ;

Cao, Xuhong ;

Byun, Jaeman ;

Omenn, Gilbert S. ;

Ghosh, Debashis ;

Pennathur, Subramaniam ;

Alexander, Danny C. ;

Berger, Alvin ;

Shuster, Jeffrey R. ;

Wei, John T. ;

Varambally, Sooryanarayana ;

Beecher, Christopher ;

Chinnaiyan, Arul M. .

NATURE, 2009, 457 (7231) :910-914

[24] Human metabolic individuality in biomedical and pharmaceutical research [J].

Suhre, Karsten ;

Shin, So-Youn ;

Petersen, Ann-Kristin ;

Mohney, Robert P. ;

Meredith, David ;

Waegele, Brigitte ;

Altmaier, Elisabeth ;

Deloukas, Panos ;

Erdmann, Jeanette ;

Grundberg, Elin ;

Hammond, Christopher J. ;

Hrabe de Angelis, Martin ;

Kastenmueller, Gabi ;

Koettgen, Anna ;

Kronenberg, Florian ;

Mangino, Massimo ;

Meisinger, Christa ;

Meitinger, Thomas ;

Mewes, Hans-Werner ;

Milburn, Michael V. ;

Prehn, Cornelia ;

Raffler, Johannes ;

Ried, Janina S. ;

Roemisch-Margl, Werner ;

Samani, Nilesh J. ;

Small, Kerrin S. ;

Wichmann, H. -Erich ;

Zhai, Guangju ;

Illig, Thomas ;

Spector, Tim D. ;

Adamski, Jerzy ;

Soranzo, Nicole ;

Gieger, Christian .

NATURE, 2011, 477 (7362) :54-U60

[25] Ethylene Glycol Monomethyl Ether-Induced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family [J].

Takei, Makoto ;

Ando, Yosuke ;

Saitoh, Wataru ;

Tanimoto, Tomoe ;

Kiyosawa, Naoki ;

Manabe, Sunao ;

Sanbuissho, Atsushi ;

Okazaki, Osamu ;

Iwabuchi, Haruo ;

Yamoto, Takashi ;

Adam, Klaus-Peter ;

Weiel, James E. ;

Ryals, John A. ;

Milburn, Michael V. ;

Guo, Lining .

TOXICOLOGICAL SCIENCES, 2010, 118 (02) :643-652

[26] Mass spectrometry for the evaluation of cardiovascular diseases based on proteomics and lipidomics [J].

Thomas, Aurelien ;

Lenglet, Sebastien ;

Chaurand, Pierre ;

Deglon, Julien ;

Mangin, Patrice ;

Mach, Francois ;

Steffens, Sabine ;

Wolfender, Jean-Luc ;

Staub, Christian .

THROMBOSIS AND HAEMOSTASIS, 2011, 106 (01) :20-33

[27]

Urbinati Fabrizia, 2006, Expert Reviews in Molecular Medicine, V8, P1, DOI 10.1017/S1462399406010805

[28] The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors [J].

Watson, Mark ;

Roulston, Anne ;

Belec, Laurent ;

Billot, Xavier ;

Marcellus, Richard ;

Bedard, Dominique ;

Bernier, Cynthia ;

Branchaud, Stephane ;

Chan, Helen ;

Dairi, Kenza ;

Gilbert, Karine ;

Goulet, Daniel ;

Gratton, Michel-Olivier ;

Isakau, Henady ;

Jang, Anne ;

Khadir, Abdelkrim ;

Koch, Elizabeth ;

Lavoie, Manon ;

Lawless, Michael ;

Nguyen, Mai ;

Paquette, Denis ;

Turcotte, Emilie ;

Berger, Alvin ;

Mitchell, Matthew ;

Shore, Gordon C. ;

Beauparlant, Pierre .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (21) :5872-5888

[29] A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23 [J].

Wu, Xifeng ;

Scelo, Ghislaine ;

Purdue, Mark P. ;

Rothman, Nathaniel ;

Johansson, Mattias ;

Ye, Yuanqing ;

Wang, Zhaoming ;

Zelenika, Diana ;

Moore, Lee E. ;

Wood, Christopher G. ;

Prokhortchouk, Egor ;

Gaborieau, Valerie ;

Jacobs, Kevin B. ;

Chow, Wong-Ho ;

Toro, Jorge R. ;

Zaridze, David ;

Lin, Jie ;

Lubinski, Jan ;

Trubicka, Joanna ;

Szeszenia-Dabrowska, Neonilia ;

Lissowska, Jolanta ;

Rudnai, Peter ;

Fabianova, Eleonora ;

Mates, Dana ;

Jinga, Viorel ;

Bencko, Vladimir ;

Slamova, Alena ;

Holcatova, Ivana ;

Navratilova, Marie ;

Janout, Vladimir ;

Boffetta, Paolo ;

Colt, Joanne S. ;

Davis, Faith G. ;

Schwartz, Kendra L. ;

Banks, Rosamonde E. ;

Selby, Peter J. ;

Harnden, Patricia ;

Berg, Christine D. ;

Hsing, Ann W. ;

Grubb, Robert L., III ;

Boeing, Heiner ;

Vineis, Paolo ;

Clavel-Chapelon, Francoise ;

Palli, Domenico ;

Tumino, Rosario ;

Krogh, Vittorio ;

Panico, Salvatore ;

Duell, Eric J. ;

Ramon Quiros, Jose ;

Sanchez, Maria-Jose .

HUMAN MOLECULAR GENETICS, 2012, 21 (02) :456-462

[30] Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists [J].

Zgoda-Pols, Joanna R. ;

Chowdhury, Swapan ;

Wirth, Mark ;

Milburn, Michael V. ;

Alexander, Danny C. ;

Alton, Kevin B. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2011, 255 (01) :48-56

← 1 2 3 4 →