Will a healthy lifestyle help prevent Alzheimer's disease?

被引：88

作者：

Pope, SK ^{[1
]}

Shue, VM ^{[1
]}

Beck, C ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72205 USA

来源：

ANNUAL REVIEW OF PUBLIC HEALTH | 2003年 / 24卷

关键词：

antioxidants; cognitive impairment; risk factors; diet; exercise;

D O I：

10.1146/annurev.publhealth.24.100901.141015

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Alzheimer's disease (AD) appears to resemble other chronic diseases, whereby a myriad of interconnected factors, including those associated with lifestyle, are involved in disease development. In this paper, we examine accepted and proposed risk factors for AD and explore health behaviors, including diet, exercise, prevention of injury, and cognitive stimulation, that may help prevent AD. Adherence to a healthy lifestyle may directly protect against AD or may prevent diseases associated with AD, such as vascular disease and diabetes. A healthy lifestyle to prevent AD may be important throughout life rather than after disease manifestation and may be particularly relevant if other factors, such as genetic predisposition, also increase risk of AD. If changes in lifestyle can help prevent AD by reducing modifiable risk factors, this knowledge can aid individuals who wish to take action to protect themselves and their families from the disease.

引用

页码：111 / 132

页数：22

共 98 条

[61]

Nicoll JAR, 2000, ANN NEUROL, V47, P365, DOI 10.1002/1531-8249(200003)47:3<365::AID-ANA13>3.3.CO

[62]

2-7

[63] Serum total cholesterol, apolipoprotein E ε4 allele, and Alzheimer's disease [J].

Notkola, IL ;

Sulkava, R ;

Pekkanen, J ;

Erkinjuntti, T ;

Ehnholm, C ;

Kivinen, P ;

Tuomilehto, A ;

Nissinen, A .

NEUROEPIDEMIOLOGY, 1998, 17 (01) :14-20

[64] A four year prospective study of age-related cognitive change in adults with Down's syndrome [J].

Oliver, C ;

Crayton, L ;

Holland, A ;

Hall, S ;

Bradbury, J .

PSYCHOLOGICAL MEDICINE, 1998, 28 (06) :1365-1377

[65]

ONER P, 1991, RES COMMUN CHEM PATH, V72, P337

[66] Intensive lifestyle changes for reversal of coronary heart disease [J].

Ornish, D ;

Scherwitz, LW ;

Billings, JH ;

Gould, KL ;

Merritt, TA ;

Sparler, S ;

Armstrong, WT ;

Ports, TA ;

Kirkeeide, RL ;

Hogeboom, C ;

Brand, RJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (23) :2001-2007

[67]

Ortega RM, 1997, AM J CLIN NUTR, V66, P803

[68] Education and the incidence of dementia in a large population-based study: The Rotterdam Study [J].

Ott, A ;

van Rossum, CTM ;

van Harskamp, F ;

van de Mheen, H ;

Hofman, A ;

Breteler, MMB .

NEUROLOGY, 1999, 52 (03) :663-666

[69] Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies - The Honolulu-Asia Aging Study [J].

Peila, R ;

Rodriguez, BL ;

Launer, LJ .

DIABETES, 2002, 51 (04) :1256-1262

[70]

Persson G, 1996, INT J GERIATR PSYCH, V11, P15, DOI 10.1002/(SICI)1099-1166(199601)11:1<15::AID-GPS262>3.0.CO

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