Regiocontrolled oxidative cyclizations of 3-substituted indoles are described herein. Specifically, it is shown that the installation of a chloride at C2 alters the Inherent propensity for cyclization at the 2-position of indole so as to favor the 4-position, enabling the construction of the unique framework found In most welwitindolinone alkaloids. The chloride functions here as more than a blocking group, as it also provides ready access to the corresponding oxindole.
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Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Boissel, Valerie
Simpkins, Nigel S.
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Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Simpkins, Nigel S.
Bhalay, Gurdip
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Horsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Bhalay, Gurdip
Blake, Alexander J.
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Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Blake, Alexander J.
Lewis, William
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Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
机构:
Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Boissel, Valerie
Simpkins, Nigel S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Simpkins, Nigel S.
Bhalay, Gurdip
论文数: 0引用数: 0
h-index: 0
机构:
Horsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Bhalay, Gurdip
Blake, Alexander J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
Blake, Alexander J.
Lewis, William
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham, Sch Chem, Nottingham NG7 2RD, EnglandHorsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England