Rings, bracelets, sleeves, and chevrons: new structures of kinetochore proteins

被引：23

作者：

Davis, Trisha N. ^{[1
]}

Wordeman, Linda

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[2] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 08期

关键词：

D O I：

10.1016/j.tcb.2007.08.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Electron microscopy has recently revealed striking structural orderliness in kinetochore proteins and protein complexes that associate with microtubules. In addition to their astonishing appearance and intrinsic beauty, the structures are functionally informative. The Dam1 and Ndc80 complexes bind to the microtubule lattice as rings and chevrons, respectively. These structures give insight into how the kinetochore couples to dynamic microtubules, a process crucial to the accurate segregation of chromosomes. HURP and kinesin-13 arrange tubulin into sleeves and bracelets surrounding the microtubule lattice. These structures might reflect the ability of these proteins to modulate microtubule dynamics by interacting with specialized tubulin configurations. In this review, we compare and contrast the structure of these proteins and their interactions with microtubules to illustrate how they attach to and modulate the dynamics of microtubules.

引用

页码：377 / 382

页数：6

共 43 条

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