The clinical potential of microRNAs

被引：89

作者：

Budhu, Anuradha ^{[1
]}

Ji, Junfang ^{[1
]}

Wang, Xin W. ^{[1
]}

机构：

[1] NCI, Liver Carcinogenesis Sect, Human Carcinogenesis Lab, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2010年 / 3卷

关键词：

SMALL INTERFERING RNA; HUMAN LUNG CANCERS; REAL-TIME PCR; IN-VIVO; HEPATOCELLULAR-CARCINOMA; EXPRESSION PROFILES; PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES; GENE-EXPRESSION; SIGNATURES; PRECURSOR;

D O I：

10.1186/1756-8722-3-37

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MicroRNAs are small noncoding RNAs that function to control gene expression. These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. In addition, microRNAs have been associated with cancer progression. In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed.

引用

页数：7

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