Transmission, acute HIV-1 infection and the quest for strategies to prevent infection

被引:273
作者
Pope, M
Haase, AT
机构
[1] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA
[2] Populat Council, Ctr Biomed Res, New York, NY 10021 USA
关键词
D O I
10.1038/nm0703-847
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
By the acute stage of HIV-1 infection, the immune system already faces daunting challenges. Research on mucosal barriers and the events immediately after heterosexual transmission that precede this acute stage could facilitate the development of effective microbicides and vaccines.
引用
收藏
页码:847 / 852
页数:6
相关论文
共 92 条
[21]   MASSIVE COVERT INFECTION OF HELPER T-LYMPHOCYTES AND MACROPHAGES BY HIV DURING THE INCUBATION PERIOD OF AIDS [J].
EMBRETSON, J ;
ZUPANCIC, M ;
RIBAS, JL ;
BURKE, A ;
RACZ, P ;
TENNERRACZ, K ;
HAASE, AT .
NATURE, 1993, 362 (6418) :359-362
[22]   Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV [J].
Enose, Y ;
Ui, M ;
Miyake, A ;
Suzuki, H ;
Uesaka, H ;
Kuwata, T ;
Kunisawa, J ;
Kiyono, H ;
Takahashi, H ;
Miura, T ;
Hayami, M .
VIROLOGY, 2002, 298 (02) :306-316
[23]   LYMPHOID GERMINAL-CENTERS ARE RESERVOIRS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA [J].
FOX, CH ;
TENNERRACZ, K ;
RACZ, P ;
FIRPO, A ;
PIZZO, PA ;
FAUCI, AS .
JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (06) :1051-1057
[24]  
Frank I., 2002, Current Molecular Medicine (Hilversum), V2, P229, DOI 10.2174/1566524024605716
[25]   DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells [J].
Geijtenbeek, TBH ;
Kwon, DS ;
Torensma, R ;
van Vliet, SJ ;
van Duijnhoven, GCF ;
Middel, J ;
Cornelissen, ILMHA ;
Nottet, HSLM ;
KewalRamani, VN ;
Littman, DR ;
Figdor, CG ;
van Kooyk, Y .
CELL, 2000, 100 (05) :587-597
[26]   Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS [J].
Goulder, PJR ;
Phillips, RE ;
Colbert, RA ;
McAdam, S ;
Ogg, G ;
Nowak, MA ;
Giangrande, P ;
Luzzi, G ;
Morgan, B ;
Edwards, A ;
McMichael, AJ ;
RowlandJones, S .
NATURE MEDICINE, 1997, 3 (02) :212-217
[27]   Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells [J].
Granelli-Piperno, A ;
Delgado, E ;
Finkel, V ;
Paxton, W ;
Steinman, RM .
JOURNAL OF VIROLOGY, 1998, 72 (04) :2733-2737
[28]   Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda [J].
Gray, RH ;
Wawer, MJ ;
Brookmeyer, R ;
Sewankambo, NK ;
Serwadda, D ;
Wabwire-Mangen, F ;
Lutalo, T ;
Li, XB ;
vanCott, T ;
Quinn, TC .
LANCET, 2001, 357 (9263) :1149-1153
[29]   Memory CD4+ T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system [J].
Gupta, P ;
Collins, KB ;
Ratner, D ;
Watkins, S ;
Naus, GJ ;
Landers, DV ;
Patterson, BK .
JOURNAL OF VIROLOGY, 2002, 76 (19) :9868-9876
[30]   Quantitative image analysis of HIV-1 infection in lymphoid tissue [J].
Haase, AT ;
Henry, K ;
Zupancic, M ;
Sedgewick, G ;
Faust, RA ;
Melroe, H ;
Cavert, W ;
Gebhard, K ;
Staskus, K ;
Zhang, ZQ ;
Dailey, PJ ;
Balfour, HH ;
Erice, A ;
Perelson, AS .
SCIENCE, 1996, 274 (5289) :985-989