Transmission, acute HIV-1 infection and the quest for strategies to prevent infection

被引：273

作者：

Pope, M

Haase, AT

机构：

[1] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA

[2] Populat Council, Ctr Biomed Res, New York, NY 10021 USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 07期

关键词：

D O I：

10.1038/nm0703-847

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By the acute stage of HIV-1 infection, the immune system already faces daunting challenges. Research on mucosal barriers and the events immediately after heterosexual transmission that precede this acute stage could facilitate the development of effective microbicides and vaccines.

引用

收藏

页码：847 / 852

页数：6

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共 92 条

[51] Progesterone implants enhance SIV vaginal transmission and early virus load [J].

Marx, PA ;

Spira, AI ;

Gettie, A ;

Dailey, PJ ;

Veazey, RS ;

Lackner, AA ;

Mahoney, CJ ;

Miller, CJ ;

Claypool, LE ;

Ho, DD ;

Alexander, NJ .

NATURE MEDICINE, 1996, 2 (10) :1084-1089

[52] Recruitment of HIV and its receptors to dendritic cell-T cell junctions [J].

McDonald, D ;

Wu, L ;

Bohks, SM ;

KewalRamani, VN ;

Unutmaz, D ;

Hope, TJ .

SCIENCE, 2003, 300 (5623) :1295-1297

[53] Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells [J].

Meng, G ;

Wei, XP ;

Wu, XY ;

Sellers, MT ;

Decker, JM ;

Moldoveanu, Z ;

Orenstein, JM ;

Graham, MF ;

Kappes, JC ;

Mestecky, J ;

Shaw, GM ;

Smith, PD .

NATURE MEDICINE, 2002, 8 (02) :150-156

[54] Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells [J].

Messmer, D ;

Jacqué, JM ;

Santisteban, C ;

Bristow, C ;

Hang, SY ;

Villamide-Herrera, L ;

Mehlhop, E ;

Marx, PA ;

Steinman, RM ;

Gettie, A ;

Pope, M .

JOURNAL OF IMMUNOLOGY, 2002, 169 (08) :4172-4182

[55] In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques [J].

Miller, CJ ;

Marthas, M ;

Greenier, J ;

Lu, D ;

Dailey, PJ ;

Lu, YC .

JOURNAL OF VIROLOGY, 1998, 72 (04) :3248-3258

[56] GENITAL MUCOSAL TRANSMISSION OF SIMIAN IMMUNODEFICIENCY VIRUS - ANIMAL-MODEL FOR HETEROSEXUAL TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS [J].

MILLER, CJ ;

ALEXANDER, NJ ;

SUTJIPTO, S ;

LACKNER, AA ;

GETTIE, A ;

HENDRICKX, AG ;

LOWENSTINE, LJ ;

JENNINGS, M ;

MARX, PA .

JOURNAL OF VIROLOGY, 1989, 63 (10) :4277-4284

[57] Rhesus macaques previously infected with Simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239 [J].

Miller, CJ ;

McChesney, MB ;

Lu, XS ;

Dailey, PJ ;

Chutkowksi, C ;

Lu, D ;

Brosio, P ;

Roberts, B ;

Lu, LC .

JOURNAL OF VIROLOGY, 1997, 71 (03) :1911-1921

[58] ASSOCIATION OF CERVICAL ECTOPY WITH HETEROSEXUAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS - RESULTS OF A STUDY OF COUPLES IN NAIROBI, KENYA [J].

MOSS, GB ;

CLEMETSON, D ;

DCOSTA, L ;

PLUMMER, FA ;

NDINYAACHOLA, JO ;

REILLY, M ;

HOLMES, KK ;

PIOT, P ;

MAITHA, GM ;

HILLIER, SL ;

KIVIAT, NC ;

CAMERON, CW ;

WAMOLA, IA ;

KREISS, JK .

JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (03) :588-591

[59] Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection [J].

Mothé, BR ;

Horton, H ;

Carter, DK ;

Allen, TM ;

Liebl, ME ;

Skinner, P ;

Vogel, TU ;

Fuenger, S ;

Vielhuber, K ;

Rehrauer, W ;

Wilson, N ;

Franchini, G ;

Altman, JD ;

Haase, A ;

Picker, LJ ;

Allison, DB ;

Watkins, DI .

JOURNAL OF VIROLOGY, 2002, 76 (02) :875-884

[60] LYMPHOID ORGANS FUNCTION AS MAJOR RESERVOIRS FOR HUMAN-IMMUNODEFICIENCY-VIRUS [J].

PANTALEO, G ;

GRAZIOSI, C ;

BUTINI, L ;

PIZZO, PA ;

SCHNITTMAN, SM ;

KOTLER, DP ;

FAUCI, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9838-9842

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