Increasing rates and scope of reactions: Sluggish amines in microwave-heated aminocarbonylation reactions under air

被引：229

作者：

Wannberg, J ^{[1
]}

Larhed, M ^{[1
]}

机构：

[1] Uppsala Univ, Biomed Ctr, Dept Organ Pharmaceut Chem, SE-75123 Uppsala, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 14期

关键词：

D O I：

10.1021/jo034382d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Commercially available molybdenum hexacarbonyl serves as a convenient and solid carbon monoxide source in palladium-catalyzed aminocarbonylations of aryl bromides and iodides. This improved microwave protocol, relying on DBU as base and THIP as solvent, enables rapid couplings using otherwise sluggish anilines, tert-butylamine, and free amino acids. In addition, Cr(CO)(6) and W(CO)(6) were found to be useful alternative CO releasing reagents. Altogether, 16 different aromatic amides were synthesized under air in 35-95% yield after only 15 min of controlled microwave irradiation.

引用

页码：5750 / 5753

页数：4

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