Determinants of Resident Tissue Macrophage Identity and Function

被引：388

作者：

Bleriot, Camille ^{[1
]}

Chakarov, Svetoslav ^{[1
]}

Ginhoux, Florent ^{[1
,2
,3
]}

机构：

[1] ASTAR, Singapore Immunol Network SIgN, Biopolis, 8A Biomed Grove,Immunos Bldg 3-4, Singapore 138648, Singapore

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, 280 South Chongqing Rd, Shanghai 200025, Peoples R China

[3] SingHlth Duke NUS Acad Med Ctr, Translat Immunol Inst, Singapore 169856, Singapore

来源：

IMMUNITY | 2020年 / 52卷 / 06期

关键词：

MONOCYTE-DERIVED MACROPHAGES; YOLK-SAC; STEM-CELLS; ANALYSIS REVEALS; GENE-EXPRESSION; FETAL LIVER; ALVEOLAR MACROPHAGES; AORTIC ENDOTHELIUM; MICROGLIA DERIVE; ADULT MICROGLIA;

D O I：

10.1016/j.immuni.2020.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related tissue-supporting activities. The roots of this heterogeneity and versatility are only beginning to be understood. Here, we propose a conceptual framework for considering the RTM heterogeneity that organizes the factors shaping RTM identity within four cardinal points: (1) ontogeny and the view that adult RTM populations comprise a defined mixture of cells that arise from either embryonic precursors or adult monocytes; (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of macrophages to their dynamic environment. We review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.

引用

页码：957 / 970

页数：14

共 157 条

[1]

Phagocytosis imprints heterogeneity in tissue-resident macrophages [J].

A-Gonzalez, Noelia ;

Quintana, Juan A. ;

Garcia-Silva, Susana ;

Mazariegos, Marina ;

Gonzalez de la Aleja, Arturo ;

Nicolas-Avila, Jose A. ;

Walter, Wencke ;

Adrover, Jose M. ;

Crainiciuc, Georgiana ;

Kuchroo, Vijay K. ;

Rothlin, Carla V. ;

Peinado, Hector ;

Castrillo, Antonio ;

Ricote, Mercedes ;

Hidalgo, Andres .

JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (05) :1281-1296

[2]

The nuclear receptor LXRα controls the functional specialization of splenic macrophages [J].

A-Gonzalez, Noelia ;

Guillen, Jose A. ;

Gallardo, German ;

Diaz, Mercedes ;

de la Rosa, Juan V. ;

Hernandez, Irene H. ;

Casanova-Acebes, Maria ;

Lopez, Felix ;

Tabraue, Carlos ;

Beceiro, Susana ;

Hong, Cynthia ;

Lara, Pedro C. ;

Andujar, Miguel ;

Arai, Satoko ;

Miyazaki, Toru ;

Li, Senlin ;

Corbi, Angel L. ;

Tontonoz, Peter ;

Hidalgo, Andres ;

Castrillo, Antonio .

NATURE IMMUNOLOGY, 2013, 14 (08) :831-+

[3]

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases [J].

Abud, Edsel M. ;

Ramirez, Ricardo N. ;

Martinez, Eric S. ;

Healy, Luke M. ;

Nguyen, Cecilia H. H. ;

Newman, Sean A. ;

Yeromin, Andriy V. ;

Scarfone, Vanessa M. ;

Marsh, Samuel E. ;

Fimbres, Cristhian ;

Caraway, Chad A. ;

Fote, Gianna M. ;

Madany, Abdullah M. ;

Agrawal, Anshu ;

Kayed, Rakez ;

Gylys, Karen H. ;

Cahalan, Michael D. ;

Cummings, Brian J. ;

Antel, Jack P. ;

Mortazavi, Ali ;

Carson, Monica J. ;

Poon, Wayne W. ;

Blurton-Jones, Mathew .

NEURON, 2017, 94 (02) :278-+

[4]

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection [J].

Aegerter, Helena ;

Kulikauskaite, Justina ;

Crotta, Stefania ;

Patel, Harshil ;

Kelly, Gavin ;

Hessel, Edith M. ;

Mack, Matthias ;

Beinke, Soren ;

Wack, Andreas .

NATURE IMMUNOLOGY, 2020, 21 (02) :145-+

[5]

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life [J].

Ajami, Bahareh ;

Bennett, Jami L. ;

Krieger, Charles ;

Tetzlaff, Wolfram ;

Rossi, Fabio M. V. .

NATURE NEUROSCIENCE, 2007, 10 (12) :1538-1543

[6]

Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain [J].

Alliot, F ;

Godin, I ;

Pessac, B .

DEVELOPMENTAL BRAIN RESEARCH, 1999, 117 (02) :145-152

[7]

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain [J].

Askew, Katharine ;

Li, Kaizhen ;

Olmos-Alonso, Adrian ;

Garcia-Moreno, Fernando ;

Liang, Yajie ;

Richardson, Philippa ;

Tipton, Tom ;

Chapman, Mark A. ;

Riecken, Kristoffer ;

Beccari, Sol ;

Sierra, Amanda ;

Molnar, Zoltan ;

Cragg, Mark S. ;

Garaschuk, Olga ;

Perry, V. Hugh ;

Gomez-Nicola, Diego .

CELL REPORTS, 2017, 18 (02) :391-405

[8]

Bain C.C., 2019, BIORXIV, DOI [10.1101/837336, DOI 10.1101/837336]

[9]

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice [J].

Bain, Calum C. ;

Bravo-Blas, Alberto ;

Scott, Charlotte L. ;

Perdiguero, Elisa Gomez ;

Geissmann, Frederic ;

Henri, Sandrine ;

Malissen, Bernard ;

Osborne, Lisa C. ;

Artis, David ;

Mowat, Allan Mci .

NATURE IMMUNOLOGY, 2014, 15 (10) :929-U236

[10]

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry [J].

Bandura, Dmitry R. ;

Baranov, Vladimir I. ;

Ornatsky, Olga I. ;

Antonov, Alexei ;

Kinach, Robert ;

Lou, Xudong ;

Pavlov, Serguei ;

Vorobiev, Sergey ;

Dick, John E. ;

Tanner, Scott D. .

ANALYTICAL CHEMISTRY, 2009, 81 (16) :6813-6822

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