β-peptides:: From structure to function

被引:1752
作者
Cheng, RP
Gellman, SH [1 ]
DeGrado, WF
机构
[1] Univ Penn, Sch Med, Dept Biochem & Biophys, Johnson Res Fdn, Philadelphia, PA 19104 USA
[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
关键词
D O I
10.1021/cr000045i
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The techniques used for designing biomimetic polymers which showed both secondary and tertiary structures analogous to natural proteins were discussed. A series of cyclic β-peptides and mixed α- and β-peptides that self-assemble to form tubular architectures were also studied. The results revealed that the polymeric β-peptides were capable of adopting stable helical structures.
引用
收藏
页码:3219 / 3232
页数:14
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