Myogenic induction of aligned mesenchymal stem cell sheets by culture on thermally responsive electrospun nanofibers

被引：185

作者：

Dang, Jiyoung M.

Leong, Kam W.

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 19期

关键词：

D O I：

10.1002/adma.200602159

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

A thermally reversible culture substrate with a topographically active surface of aligned nanofibers is able to induce cytoskeletal alignment and nucleus elongation. These morphological changes induce myogenic differentiation in stem cells. The differentiated cells can be recovered in sheet form by thermally induced dissolution of the substrate. A surface able to provide topographical cues to create an aligned stem cell sheet, activated to differentiate to a specific lineage, can have a significant impact on engineering of tissue constructs for regenerative medicine applications.

引用

收藏

页码：2775 / +

页数：6

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