Novel biodegradable copolymers containing pendant amine functional groups based on aspartic acid and poly(ethylene glycol)

被引：49

作者：

Won, CY

Chu, CC ^{[1
]}

Lee, JD

机构：

[1] Cornell Univ, Dept Text & Apparel, Fiber & Polymer Sci Program, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA

来源：

POLYMER | 1998年 / 39卷 / 25期

关键词：

aspartic acid anhydride; poly(ethylene glycol); biodegradable;

D O I：

10.1016/S0032-3861(98)00032-9

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new biodegradable poly(L-aspartic acid-co-poly(ethylene glycol)) having pendant amine functional groups was synthesized by the melt polycondensation reaction of prepolymer prepared from N-(benzyloxycarbonyl)-L-aspartic acid anhydride (N-Z-L-aspartic acid anhydride) and poly(ethylene glycol). The synthesized polymer was characterized by FTi.r., H-1 n.m.r., d.s.c., g.p.c. and solubility. The weight-average molecular weight of the prepolymer increased about 11 times via melt polycondensation at 160 degrees C in a vacuum for <1 h. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6677 / 6681

页数：5

共 17 条

[1] TETRAETHYL PYROPHOSPHITE AS A REAGENT FOR PEPTIDE SYNTHESES [J].