Solid-phase synthesis of oligomeric deoxynucleic guanidine (DNG): A polycationic analogue of DNA

被引：23

作者：

Linkletter, BA ^{[1
]}

Bruice, TC ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem, Santa Barbara, CA 93106 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(98)00228-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

DNG is a DNA analogue wherein the negatively charged phosphate backbone linkages have been replaced by achiral positively charged guanidinium linkages and has high affinity for complimentary DNA. The synthesis of these compounds in solution phase has been severely limited due to diminishing yields and solubility limitations. For the first time, an efficient solid-phase synthesis for oligomeric is reported. (C) 1998 Elsevier Science Ltd. Ail rights reserved.

引用

页码：1285 / 1290

页数：6

共 27 条

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