Homeobox gene mutations and brain-stem developmental disorders: learning from knockout mice

被引：8

作者：

Pasqualetti, M ^{[1
]}

Rijli, FM ^{[1
]}

机构：

[1] Coll France, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM,ULP,CU Strasbourg, F-67404 Illkirch Graffenstaden, France

来源：

CURRENT OPINION IN NEUROLOGY | 2001年 / 14卷 / 02期

关键词：

D O I：

10.1097/00019052-200104000-00007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Analysis of mice that carry targeted inactivations of Hox, Nkx and Phox2 homeobox genes revealed their involvement in regional patterning of brain-stem territories, in specification of neuronal identity, in establishment of appropriate patterns of connectivity and in control of neurotransmission. The specific abnormalities generated by such mutations may provide clues to the genetic basis and cellular mechanisms that are involved in human brain-stem developmental disorders. Curr Opin Neurol 14:177-184. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：177 / 184

页数：8

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