Stroke and the immune system: from pathophysiology to new therapeutic strategies

被引：458

作者：

Macrez, Richard ^{[1
,2
,3
]}

Ali, Carine ^{[1
]}

Toutirais, Olivier ^{[1
,2
,3
,4
]}

Le Mauff, Brigitte ^{[1
,2
,3
,4
]}

Defer, Gilles ^{[1
,2
,3
]}

Dirnagl, Ulrich ^{[5
,6
,7
]}

Vivien, Denis ^{[1
]}

机构：

[1] INSERM, Serine Proteases & Pathophysiol Neurovasc Unit, CNRS, UMR CiNAPS 6232,U919, F-14074 Caen, France

[2] Ctr Hosp, Serv Neurol, Caen, France

[3] Univ Caen, F-14032 Caen, France

[4] Ctr Hosp, Lab Immunol & Immunopathol, Caen, France

[5] Charite, Dept Neurol, D-13353 Berlin, Germany

[6] Charite, Dept Expt Neurol, D-13353 Berlin, Germany

[7] Ctr Stroke Res Berlin, Berlin, Germany

来源：

LANCET NEUROLOGY | 2011年 / 10卷 / 05期

关键词：

FOCAL CEREBRAL-ISCHEMIA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TISSUE-PLASMINOGEN ACTIVATOR; PREVENTIVE ANTIBACTERIAL THERAPY; TUMOR-NECROSIS-FACTOR; BRAIN-DAMAGE; INDUCED IMMUNODEPRESSION; INFLAMMATORY MECHANISMS; INFLUENZA VACCINATION; REDUCES INFLAMMATION;

D O I：

10.1016/S1474-4422(11)70066-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stroke is the second most common cause of death worldwide and a major cause of acquired disability in adults. Despite tremendous progress in understanding the pathophysiology of stroke, translation of this knowledge into effective therapies has largely failed, with the exception of thrombolysis, which only benefits a small proportion of patients. Systemic and local immune responses have important roles in causing stroke and are implicated in the primary and secondary progression of ischaemic lesions, as well as in repair, recovery, and overall outcome after a stroke. However, potential therapeutic targets in the immune system and inflammatory responses have not been well characterised. Development of novel and effective therapeutic strategies for stroke will require further investigation of these pathways in terms of their temporal profile (before, during, and after stroke) and risk-to-benefit therapeutic ratio of modulating them.

引用

页码：471 / 480

页数：10

共 134 条

[51] Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody - A bedside-to-bench study [J].