Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections

被引：283

作者：

Ben-David, D. ^{[1
]}

Kordevani, R. ^{[1
]}

Keller, N. ^{[1
]}

Tal, I. ^{[1
]}

Marzel, A. ^{[1
]}

Gal-Mor, O. ^{[1
]}

Maor, Y. ^{[1
]}

Rahav, G. ^{[1
]}

机构：

[1] Chaim Sheba Med Ctr, Infect Dis Unit, IL-52621 Tel Hashomer, Israel

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 01期

关键词：

Bloodstream infection; carbapenem resistance; Klebsiella pneumoniae; outcome; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; INTENSIVE-CARE-UNIT; NEW-YORK-CITY; MOLECULAR EPIDEMIOLOGY; ESCHERICHIA-COLI; RISK-FACTORS; CLINICAL-OUTCOMES; BETA-LACTAMASES; BACTEREMIA; MORTALITY;

D O I：

10.1111/j.1469-0691.2011.03478.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was to evaluate the impact of carbapenem-resistant K. pneumoniae bloodstream infections on mortality. During the study period 42, 68 and 120 patients were identified with carbapenem-resistant, extended-spectrum beta-lactamase producers (ESBL) and susceptible K. pneumoniae bloodstream infections, respectively. Patients with carbapenem-resistant K. pneumoniae had higher rates of prior antimicrobial exposure, other nosocomial infections, and use of invasive devices. Infection-related mortality was 48% for carbapenem-resistant, 22% for ESBL producers and 17% for susceptible K. pneumoniae. Independent risk factors for infection-related mortality were Pitt bacteraemia score, Charlson score and carbapenem resistance.

引用

页码：54 / 60

页数：7

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