Lymphocyte calcium signaling from membrane to nucleus

被引：154

作者：

Gallo, EM

Canté-Barrett, K

Crabtree, GR ^{[1
]}

机构：

[1] Stanford Univ, Program Immunol, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 01期

关键词：

D O I：

10.1038/ni1295

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+-dependent transcription regulates lymphocyte function.

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页码：25 / 32

页数：8

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