Trends in ultrasensitive proteomics

被引：96

作者：

Altelaar, A. F. Maarten ^{[1
,2
,3
]}

Heck, Albert J. R. ^{[1
,2
,3
]}

机构：

[1] Univ Utrecht, Biomol Mass Spectrometry & Prote Grp, Bijvoet Ctr Biomol Res, NL-3584 CH Utrecht, Netherlands

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3584 CH Utrecht, Netherlands

[3] Netherlands Prote Ctr, NL-3584 CH Utrecht, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2012年 / 16卷 / 1-2期

关键词：

LTQ-ORBITRAP VELOS; MASS-SPECTROMETRY; SINGLE CELLS; REVEALS; CANCER; IDENTIFICATION; SEPARATION; CYTOMETRY; PEPTIDES; NETWORKS;

D O I：

10.1016/j.cbpa.2011.12.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we review recent developments and trends in sample preparation, pre-fractionation, chromatography and mass spectrometry contributing towards the ultra-sensitive global analysis of proteins. Highly sensitive MS-based proteomics is not only beneficiary for the proteome analysis of single cells, an aim which is getting into reach, but also clearly relevant for the analysis of (a) subcellular organelles, (b) specific low-abundant cell-types such as adult stem cells, and (c) smaller but more homogeneous cell populations sorted or dissected from (diseased) tissue.

引用

页码：206 / 213

页数：8

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