Glucocorticoid-Loaded Core-Cross-Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis

被引：128

作者：

Crielaard, Bart J. ^{[2
]}

Rijcken, Cristianne J. F. ^{[2
,3
]}

Quan, Lingdong ^{[4
]}

van der Wal, Steffen ^{[5
]}

Altintas, Isil ^{[2
]}

van der Pot, Martin ^{[2
]}

Kruijtzer, John A. W. ^{[5
]}

Liskamp, Rob M. J. ^{[5
]}

Schiffelers, Raymond M. ^{[2
,6
]}

van Nostrum, Cornelus F. ^{[2
]}

Hennink, Wim E. ^{[2
]}

Wang, Dong ^{[4
]}

Lammers, Twan ^{[1
,7
]}

Storm, Gert ^{[2
,7
]}

机构：

[1] Rhein Westfal TH Aachen, Helmholtz Inst Biomed Engn, Dept Expt Mol Imaging, D-52074 Aachen, Germany

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CG Utrecht, Netherlands

[3] Cristal Delivery BV, Utrecht, Netherlands

[4] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE USA

[5] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TC Utrecht, Netherlands

[6] Univ Med Ctr Utrecht, Dept Clin Chem & Haematol, Utrecht, Netherlands

[7] Univ Twente, Fac Sci & Technol, Dept Targeted Therapeut, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 29期

关键词：

drug delivery; glucocorticoids; micelles; nanomedicine; rheumatoid arthritis; DRUG-DELIVERY; HPMA COPOLYMERS; IN-VIVO; LIPOSOMES; BIODISTRIBUTION; ARTHROTROPISM; NANOPARTICLES; CARRIERS; DESIGN;

D O I：

10.1002/anie.201202713

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7254 / 7258

页数：5

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