Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)

被引：47

作者：

Kops, GJPL

Burgering, BMT

机构：

[1] Univ Utrecht, Physiol Chem Lab, NL-3584 CG Utrecht, Netherlands

[2] Univ Utrecht, Ctr Biomed Genet, NL-3584 CG Utrecht, Netherlands

来源：

JOURNAL OF ANATOMY | 2000年 / 197卷

关键词：

protein kinase B; c-akt;

D O I：

10.1046/j.1469-7580.2000.19740571.x

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.

引用

收藏

页码：571 / 574

页数：4

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