Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)

被引:190
作者
Birnbaum, LS
Staskal, DF
Diliberto, JJ
机构
[1] US EPA, Div Environm Toxicol, Natl Hlth & Enviornm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA
[2] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA
关键词
health effect; PBDD; PBDF;
D O I
10.1016/S0160-4120(03)00106-5
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This article reviews the state of the science regarding the health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). While thousands of articles have been published on the health effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs), little is know about the brominated and mixed chloro/bromo homologs. Available literature suggests that brominated compounds have similar toxicity profiles to their chlorinated homologs. However, further research investigating health effects will only be useful if exposure scenarios truly exist. Current exposure data is extremely limited, posing a major data gap in assessing potential risk of these chemicals. The rapid increase in the use of brominated flame retardants has raised the level of environmental concern regarding PBDDs/PBDFs as it is likely that human, as well as wildlife, exposure to brominated dioxins and furans will increase with their use. Published by Elsevier Science Ltd.
引用
收藏
页码:855 / 860
页数:6
相关论文
共 31 条
[1]   Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment [J].
Behnisch, PA ;
Hosoe, K ;
Sakai, S .
ENVIRONMENT INTERNATIONAL, 2001, 27 (06) :495-519
[2]   Bioanalytical screening methods for dioxins and dioxin-like compounds - a review of bioassay/biomarker technology [J].
Behnisch, PA ;
Hosoe, K ;
Sakai, S .
ENVIRONMENT INTERNATIONAL, 2001, 27 (05) :413-439
[3]  
BIRNBAUM LS, 1994, PROG CLIN BIOL RES, V387, P139
[4]   TERATOGENIC EFFECTS OF 2,3,7,8-TETRABROMODIBENZO-P-DIOXIN AND 3 POLYBROMINATED DIBENZOFURANS IN C57BL/6N MICE [J].
BIRNBAUM, LS ;
MORRISSEY, RE ;
HARRIS, MW .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 107 (01) :141-152
[5]   DISPOSITION AND EXCRETION OF 2,3,4,7,8-PENTACHLORODIBENZOFURAN IN THE RAT [J].
BREWSTER, DW ;
BIRNBAUM, LS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 90 (02) :243-252
[6]   DISPOSITION OF 1,2,3,7,8-PENTACHLORODIBENZOFURAN IN THE RAT [J].
BREWSTER, DW ;
BIRNBAUM, LS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1988, 95 (03) :490-498
[7]   2,3,7,8-TETRACHLORODIBENZOFURAN TISSUE DISTRIBUTION AND EXCRETION IN GUINEA-PIGS [J].
DECAD, GM ;
BIRNBAUM, LS ;
MATTHEWS, HB .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1981, 57 (02) :231-240
[8]   THE METABOLISM OF 2,3,7,8-TETRABROMODIBENZODIOXIN IN THE RAT [J].
DEJONGH, J ;
BUSER, HR ;
POIGER, H .
XENOBIOTICA, 1993, 23 (01) :19-26
[9]   Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in mice [J].
DeVito, MJ ;
Ross, DG ;
Dupuy, AE ;
Ferrario, J ;
McDaniel, D ;
Birnbaum, LS .
TOXICOLOGICAL SCIENCES, 1998, 46 (02) :223-234
[10]   EFFECTS OF DOSE AND ROUTES OF EXPOSURE ON THE DISPOSITION OF 2,3,7,8-[H-3]TETRABROMODIBENZO-P-DIOXIN (TBDD) IN THE RAT [J].
DILIBERTO, JJ ;
KEDDERIS, LB ;
JACKSON, JA ;
BIRNBAUM, LS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1993, 120 (02) :315-326