Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)

被引：190

作者：

Birnbaum, LS

Staskal, DF

Diliberto, JJ

机构：

[1] US EPA, Div Environm Toxicol, Natl Hlth & Enviornm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA

[2] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA

来源：

ENVIRONMENT INTERNATIONAL | 2003年 / 29卷 / 06期

关键词：

health effect; PBDD; PBDF;

D O I：

10.1016/S0160-4120(03)00106-5

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This article reviews the state of the science regarding the health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). While thousands of articles have been published on the health effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs), little is know about the brominated and mixed chloro/bromo homologs. Available literature suggests that brominated compounds have similar toxicity profiles to their chlorinated homologs. However, further research investigating health effects will only be useful if exposure scenarios truly exist. Current exposure data is extremely limited, posing a major data gap in assessing potential risk of these chemicals. The rapid increase in the use of brominated flame retardants has raised the level of environmental concern regarding PBDDs/PBDFs as it is likely that human, as well as wildlife, exposure to brominated dioxins and furans will increase with their use. Published by Elsevier Science Ltd.

引用

页码：855 / 860

页数：6

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