Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase α and β

被引：75

作者：

Hanashima, S

Mizushima, Y

Yamazaki, T

Ohta, K

Takahashi, S

Sahara, H

Sakaguchi, K

Sugawara, F ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Appl Biol Sci, Chiba 2788510, Japan

[2] Inst Phys & Chem Res, Wako, Saitama 3519800, Japan

[3] Sapporo Med Univ, Sch Med, Inst Marine Biomed, Rishirifuji, Hokkaido 0970101, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0968-0896(00)00252-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sulfoquinovosyldiacylglycerols (SQDGs) and sulfoquinovosylmonoacylglycerols (SQMGs), bearing diverse fatty acids, were synthesized from D-glucose, and were examined for enzymatic inhibitions of DNA polymerase alpha and beta. These results indicated that the carbon numbers of the fatty acids were highly related to the activities, at least in vitro, of eukaryotic DNA polymerase inhibition. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：367 / 376

页数：10

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