Palladium-catalyzed synthesis of 2-aminoindoles by a heteroanulation reaction

被引：107

作者：

Witulski, B ^{[1
]}

Alayrac, C ^{[1
]}

Tevzadze-Saeftel, L ^{[1
]}

机构：

[1] Univ Kaiserslautern, Fachbereich Chem, D-67663 Kaiserslautern, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 35期

关键词：

homogeneous catalysis; indoles; nitrogen heterocycles; palladium; ynamides;

D O I：

10.1002/anie.200351977

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chelates are the key: A conceptually novel indole ring forming reaction through heteroanulation is available through the palladium-catalyzed reaction of N-alkenylanilides with primary or secondary amines. The key feature is the formation of an unprecedented σ,π-chelated palladium species (see scheme); nitrogen nucleophiles can add to the activated alkyne unit of this species to form the indole skeleton. (X = I, Br; HNR2R3= prim. or sec. amine; Ts =tosyl.).

引用

页码：4257 / 4260

页数：4

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