Metallic barcodes for multiplexed bioassays

被引：41

作者：

Brunker, Sarah E. ^{[1
]}

Cederquist, Kristin B. ^{[1
]}

Keating, Christine D. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

NANOMEDICINE | 2007年 / 2卷 / 05期

关键词：

barcoded nanowires; bioconjugate; biosensors; cancer detection; encoded particles; fluorescence; nanotechnology;

D O I：

10.2217/17435889.2.5.695

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Both detection and postdiagnosis monitoring are critical for cancer isolation and treatment. Particle-based sensing strategies could help to address these medical needs. This review describes barcoded metallic nanowires as particle scaffolds for multiplexed detection of antigens or nucleic acids. Barcode patterns are compositionally encoded as stripes of gold and silver metal along the nanowire length during fabrication by templated electrodeposition. Particle identification is accomplished using reflectance optical microscopy and can be coupled with fluorescence readout of antigen- or nucleic acid-binding events. Several approaches to multiplexed biodetection based on barcoded nanowires will be described and the potential for these particles in cancer detection will be discussed.

引用

页码：695 / 710

页数：16

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