Synthesis and properties of phosphorylated 3′-O-β-D-ribofuranosyl-2′-deoxythymidine

被引：8

作者：

Efimtseva, EV

Shelkunova, AA

Mikhailov, SN

Nauwelaerts, K

Rozenski, J

Lescrinier, E

Herdewijn, P

机构：

[1] Katholieke Univ Leuven, Rega Inst, B-3000 Louvain, Belgium

[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 04期

关键词：

disaccharide nucleosides; synthesis; NMR;

D O I：

10.1081/NCN-120022028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A strategy was developed for the synthesis of 3'-O-beta-D-ribofuranosyl 2'-deoxythymidine derivatives using three different protecting groups, which allows the synthesis of a phosphoramidite building block for oligonucleotide synthesis. Likewise the 5'-O- and 5"-O-phosphorylated analogues were synthesized and their conformation was determined using NMR spectroscopy.

引用

收藏

页码：359 / 371

页数：13

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