Potassium channels: The importance of transport signals

被引：19

作者：

Griffith, LC ^{[1
]}

机构：

[1] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0960-9822(01)00111-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number, type and distribution of ion channels on a neuron's surface determine its electrical response to stimulation. One way that a cell determines how many molecules of each channel type are sent to the surface has been eludicated in a recent study of intrinsic protein transport signals within potassium channels.

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页码：R226 / R228

页数：3

相关论文

共 16 条

[1] ACTIVITY-DEPENDENT REGULATION OF CONDUCTANCES IN MODEL NEURONS [J].

LEMASSON, G ;

MARDER, E ;

ABBOTT, LF .

SCIENCE, 1993, 259 (5103) :1915-1917

[2]

Levitan ES, 1998, J NEUROBIOL, V37, P60, DOI 10.1002/(SICI)1097-4695(199810)37:1<60::AID-NEU5>3.0.CO

[3]

2-6

[4]

Levitan IB, 1999, ADV SEC MESS PHOSPH, V33, P3

[5] Surface expression of Kv1 channels is governed by a C-terminal motif [J].

Li, DQ ;

Takimoto, K ;

Levitan, ES .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :11597-11602

[6] Role of ER export signals in controlling surface potassium channel numbers [J].

Ma, DK ;

Zerangue, N ;

Lin, YF ;

Collins, A ;

Yu, M ;

Jan, YN ;

Jan, LY .

SCIENCE, 2001, 291 (5502) :316-319

[7] A trafficking checkpoint controls GABAB receptor heterodimerization [J].

Margeta-Mitrovic, M ;

Jan, YN ;

Jan, LY .

NEURON, 2000, 27 (01) :97-106

[8] The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation [J].

Meacham, GC ;

Patterson, C ;

Zhang, WY ;

Younger, JM ;

Cyr, DM .

NATURE CELL BIOLOGY, 2001, 3 (01) :100-105

[9] A di-acidic (DXE) code directs concentration of cargo during export from the endoplasmic reticulum [J].

Nishimura, N ;

Bannykh, S ;

Slabough, S ;

Matteson, J ;

Altschuler, Y ;

Hahn, K ;

Balch, WE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (22) :15937-15946

[10]

Ribera AB, 1998, J NEUROSCI, V18, P9181