Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts

被引:54
作者
Saretzki, G
Feng, JL
von Zglinicki, T
Villeponteau, B
机构
[1] Humboldt Univ, Inst Pathol, D-10098 Berlin, Germany
[2] Geron Corp, Menlo Pk, CA USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 1998年 / 53卷 / 06期
关键词
D O I
10.1093/gerona/53A.6.B438
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Different DNA-damaging treatments produce a senescence-like phenotype. Young human fibroblasts are transferred to a senescence-like state after 4 to 6 weeks of culture under 40% ambient oxygen partial pressure. In order to understand the causes of senescence it would be advantageous to know how well this state equals accelerated senescence. Therefore, we measured;the expression of genes with known senescence-specific expression pattern in human fibroblasts, which were irreversibly proliferation-inhibited by chronic hyperoxic treatment A senescence specific gene expression pattern was confirmed by semiquantitative RT-PCR for eight out of nine examined genes in BJ foreskin fibroblasts and for four out of four genes in MRC-5 lung fibro blasts. For all these eases, gene expression under hyperoxia was similar to that in senescent cells, suggesting that chronic mild hyperoxia is a valid model for accelerated senescence.
引用
收藏
页码:B438 / B442
页数:5
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