Enantioposition-selective arylation of biaryl ditriflates by palladium-catalyzed asymmetric Grignard cross-coupling

被引：67

作者：

Kamikawa, T ^{[1
]}

Hayashi, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 11期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4020(98)01154-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric cross-coupling of achiral biaryl ditriflates with aryl Grignard reagents in the presence of 1 equiv of lithium bromide and 5 mol % of palladium complex PdCl2[(S)-alaphos], where alaphos stands for (2-dimethylamino)propyldiphenylphosphine, gave axially chiral monophenylation products with high enantioposition-selectivity. The remaining triflate group in the monophenylation products was substituted with carboxyl and diphenylphosphino groups through palladium-catalyzed carbonylation and diphenylphosphinylation, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3455 / 3466

页数：12

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