Manipulating hematopoietic stem cell amplification with Wnt

被引：10

作者：

Eaves, CJ

机构：

[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ni0603-511

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms that regulate self-renewal of hematopoietic stem cells have remained elusive. Recent papers in Nature point to an important role of the Wnt-beta-catenin signaling pathway in promoting this process.

引用

页码：511 / 512

页数：2

共 13 条

[1] HOXB4-induced expansion of adult hematopoietic stem cells ex vivo [J].

Antonchuk, J ;

Sauvageau, G ;

Humphries, RK .

CELL, 2002, 109 (01) :39-45

[2] Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis [J].

Audet, J ;

Miller, CL ;

Eaves, CJ ;

Piret, JM .

BIOTECHNOLOGY AND BIOENGINEERING, 2002, 80 (04) :393-404

[3] In vitro self-renewal division of hematopoietic stem cells [J].

Ema, H ;

Takano, H ;

Sudo, K ;

Nakauchi, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (09) :1281-1288

[4]

Iscove N, 2002, EXP HEMATOL, V30, P38

[5] A stem cell molecular signature [J].

Ivanova, NB ;

Dimos, JT ;

Schaniel, C ;

Hackney, JA ;

Moore, KA ;

Lemischka, IR .

SCIENCE, 2002, 298 (5593) :601-604

[6] Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability [J].

Miller, CL ;

Eaves, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13648-13653

[7] Stemness: Transcriptional profiling of embryonic and adult stem cells [J].

Ramalho-Santos, M ;

Yoon, S ;

Matsuzaki, Y ;

Mulligan, RC ;

Melton, DA .

SCIENCE, 2002, 298 (5593) :597-600

[8]

REYA T, 2003, NATURE

[9] DIFFERENTIAL EXPRESSION OF HOMEOBOX GENES IN FUNCTIONALLY DISTINCT CD34(+) SUBPOPULATIONS OF HUMAN BONE-MARROW CELLS [J].

SAUVAGEAU, G ;

LANSDORP, PM ;

EAVES, CJ ;

HOGGE, DE ;

DRAGOWSKA, WH ;

REID, DS ;

LARGMAN, C ;

LAWRENCE, HJ ;

HUMPHRIES, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) :12223-12227

[10] OVEREXPRESSION OF HOXB4 IN HEMATOPOIETIC-CELLS CAUSES THE SELECTIVE EXPANSION OF MORE PRIMITIVE POPULATIONS IN-VITRO AND IN-VIVO [J].

SAUVAGEAU, G ;

THORSTEINSDOTTIR, U ;

EAVES, CJ ;

LAWRENCE, HJ ;

LARGMAN, C ;

LANSDORP, PM ;

HUMPHRIES, RK .

GENES & DEVELOPMENT, 1995, 9 (14) :1753-1765

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