Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy

被引：146

作者：

Gattinoni, Luca ^{[1
]}

Ji, Yun ^{[1
]}

Restifo, Nicholas P. ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL CANCER RESEARCH | 2010年 / 16卷 / 19期

关键词：

TRANSCRIPTION FACTOR GATA-3; MEMORY STEM-CELLS; BETA-CATENIN; IN-VIVO; WNT PATHWAY; ADOPTIVE IMMUNOTHERAPY; MOLECULAR SWITCH; EFFECTOR; DIFFERENTIATION; SURVIVAL;

D O I：

10.1158/1078-0432.CCR-10-0356

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/beta-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how harnessing the Wnt/beta-catenin pathway might improve the efficacy of vaccines, T-cell-based therapies, and allogeneic stem cell transplantation for the treatment of patients with cancer. Clin Cancer Res; 16( 19); 4695-701. (C) 2010 AACR.

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页码：4695 / 4701

页数：7

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