Pathogenicity islands and phages in Vibrio cholerale evolution

被引:129
作者
Faruque, SM
Mekalanos, JJ
机构
[1] Int Ctr Diarrhoeal Dis Res, Genet Mol Lab, Dhaka 1212, Bangladesh
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
关键词
D O I
10.1016/j.tim.2003.09.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The identification of accessory genetic elements (plasmids, phages and chromosomal 'pathogenicity islands') encoding virulence-associated genes has facilitated our efforts to understand the origination of pathogenic microorganisms. Toxigenic Vibrio cholerae, the etiologic agent of cholera, represents a paradigm for this process in that this organism evolved from environmental nonpathogenic V. cholerae by acquisition of virulence genes. The major virulence genes in V. cholerae, which are clustered in several chromosomal regions, appear to have been recently acquired from phages or through undefined horizontal gene transfer events. Evidence is accumulating that the interactions of phages with each other can also influence the emergence of pathogenic clones of V. cholerae. Therefore, to track the evolution of pathogens from their nonpathogenic progenitors, it is also crucial to identify and characterize secondary genetic elements that mediate lateral transfer of virulence genes in trans. Understanding the evolutionary events that lead to the emergence of pathogenic clones might provide new approaches to the control of cholera and other infectious diseases.
引用
收藏
页码:505 / 510
页数:6
相关论文
共 45 条
  • [11] Comparative genomic analysis of Vibrio cholerae:: Genes that correlate with cholera endemic and pandemic disease
    Dziejman, M
    Balon, E
    Boyd, D
    Fraser, CM
    Heidelberg, JF
    Mekalanos, JJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) : 1556 - 1561
  • [12] RS1 element of Vibrio cholerae can propagate horizontally as a filamentous phage exploiting the morphogenesis genes of CTXΦ
    Faruque, SA
    Asadulghani
    Kamruzzaman, A
    Nandi, RK
    Ghosh, AN
    Nair, GB
    Mekalanos, JJ
    Sack, DA
    [J]. INFECTION AND IMMUNITY, 2002, 70 (01) : 163 - 170
  • [13] Analysis of clinical and environmental strains of nontoxigenic Vibrio cholerae for susceptibility to CTXΦ:: Molecular basis for origination of new strains with epidemic potential
    Faruque, SM
    Asadulghani
    Saha, MN
    Alim, ARMA
    Albert, MJ
    Islam, KMN
    Mekalanos, JJ
    [J]. INFECTION AND IMMUNITY, 1998, 66 (12) : 5819 - 5825
  • [14] Examination of diverse toxin-coregulated pilus-positive Vibrio cholerae strains fails to demonstrate evidence for Vibrio pathogenicity island phage
    Faruque, SM
    Zhu, J
    Asadulghani
    Kamruzzaman, M
    Mekalanos, JJ
    [J]. INFECTION AND IMMUNITY, 2003, 71 (06) : 2993 - 2999
  • [15] Emergence and evolution of Vibrio cholerae O139
    Faruque, SM
    Sack, DA
    Sack, RB
    Colwell, RR
    Takeda, Y
    Nair, GB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) : 1304 - 1309
  • [16] CTXΦ-independent production of the RS1 satellite phage by Vibrio cholerae
    Faruque, SM
    Kamruzzaman, M
    Asadulghani
    Sack, DA
    Mekalanos, JJ
    Nair, GB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) : 1280 - 1285
  • [17] Pathogenic potential of environmental Vibrio cholerae strains carrying genetic variants of the toxin-coregulated pilus pathogenicity island
    Faruque, SM
    Kamruzzaman, M
    Meraj, IM
    Chowdhury, N
    Nair, GB
    Sack, RB
    Colwell, RR
    Sack, DA
    [J]. INFECTION AND IMMUNITY, 2003, 71 (02) : 1020 - 1025
  • [18] Induction of the lysogenic phage encoding cholera toxin in naturally occurring strains of toxigenic Vibrio cholerae O1 and O139
    Faruque, SM
    Asadulghani
    Alim, ARMA
    Albert, MJ
    Islam, KMN
    Mekalanos, JJ
    [J]. INFECTION AND IMMUNITY, 1998, 66 (08) : 3752 - 3757
  • [19] Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae
    Faruque, SM
    Albert, MJ
    Mekalanos, JJ
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (04) : 1301 - +
  • [20] The O139 serogroup of Vibrio cholerae comprises diverse clones of epidemic and nonepidemic strains derived from multiple V. cholerae O1 or non-O1 progenitors
    Faruque, SM
    Saha, MN
    Asadulghani
    Sack, DA
    Sack, RB
    Takeda, Y
    Nair, GB
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (04) : 1161 - 1168