共 45 条
Pathogenicity islands and phages in Vibrio cholerale evolution
被引:129
作者:

Faruque, SM
论文数: 0 引用数: 0
h-index: 0
机构: Int Ctr Diarrhoeal Dis Res, Genet Mol Lab, Dhaka 1212, Bangladesh

Mekalanos, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Int Ctr Diarrhoeal Dis Res, Genet Mol Lab, Dhaka 1212, Bangladesh
机构:
[1] Int Ctr Diarrhoeal Dis Res, Genet Mol Lab, Dhaka 1212, Bangladesh
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
关键词:
D O I:
10.1016/j.tim.2003.09.003
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The identification of accessory genetic elements (plasmids, phages and chromosomal 'pathogenicity islands') encoding virulence-associated genes has facilitated our efforts to understand the origination of pathogenic microorganisms. Toxigenic Vibrio cholerae, the etiologic agent of cholera, represents a paradigm for this process in that this organism evolved from environmental nonpathogenic V. cholerae by acquisition of virulence genes. The major virulence genes in V. cholerae, which are clustered in several chromosomal regions, appear to have been recently acquired from phages or through undefined horizontal gene transfer events. Evidence is accumulating that the interactions of phages with each other can also influence the emergence of pathogenic clones of V. cholerae. Therefore, to track the evolution of pathogens from their nonpathogenic progenitors, it is also crucial to identify and characterize secondary genetic elements that mediate lateral transfer of virulence genes in trans. Understanding the evolutionary events that lead to the emergence of pathogenic clones might provide new approaches to the control of cholera and other infectious diseases.
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页码:505 / 510
页数:6
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