Recent antiviral strategies against human coronavirus-related respiratory illnesses

被引：8

作者：

Golda, Anna ^{[1
]}

Pyrc, Krzysztof ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Microbiol, Fac Biochem Biophys & Biotechnol, PL-30387 Krakow, Poland

来源：

CURRENT OPINION IN PULMONARY MEDICINE | 2008年 / 14卷 / 03期

关键词：

antiviral drugs; antiviral strategies; coronaviruses;

D O I：

10.1097/MCP.0b013e3282f7646f

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Purpose of review The main purpose of this review is to summarize the current research (2006-2007) concerning the development of novel anticoronaviral strategies and compounds. Recent findings Recent research led to the identification of several novel agents inhibiting coronaviral replication. The most promising compounds include carbohydrate-binding agents, neutralizing antibodies and drugs targeting a coronaviral envelope protein. Summary Although initial outbreaks of coronavirus that causes severe acute respiratory syndrome (SARS-CoV) were controlled by public health measures, the development of vaccines and antiviral agents for SARS-CoV is essential for improving control and treatment of future outbreaks. Four years after the SARS-CoV epidemic, several compounds with an anticoronaviral activity have been identified.

引用

页码：248 / 253

页数：6

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