Surface biology of DNA by atomic force microscopy

被引：222

作者：

Hansma, HG ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA

来源：

ANNUAL REVIEW OF PHYSICAL CHEMISTRY | 2001年 / 52卷

关键词：

biomaterials; nanotechnology; scanning probe microscopy; SFM; SPM;

D O I：

10.1146/annurev.physchem.52.1.71

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The atomic force microscope operates on surfaces. Since surfaces occupy much of the space in living organisms, surface biology is a valid and valuable form of biology that has been difficult to investigate in the past owing to a lack of good technology. Atomic force microscopy (AFM) of DNA has been used to investigate DNA condensation for gene therapy, DNA mapping and sizing, and a few applications to cancer research and to nanotechnology. Some of the most exciting new applications for atomic force microscopy of DNA involve pulling on single DNA molecules to obtain measurements of single-molecule mechanics and thermodynamics.

引用

页码：71 / 92

页数：26

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