Microextraction by packed sorbent (MEPS): A tutorial

被引：222

作者：

Abdel-Rehim, Mohamed ^{[1
,2
,3
]}

机构：

[1] AstraZeneca R&D Sodertalje, Global DMPK, SE-15185 Sodertalje, Sweden

[2] Stockholm Univ, Dept Analyt Chem, SE-10691 Stockholm, Sweden

[3] Karlstad Univ, Dept Chem & Biomed Sci, Fac Sci & Technol, SE-65188 Karlstad, Sweden

来源：

ANALYTICA CHIMICA ACTA | 2011年 / 701卷 / 02期

关键词：

Sample preparation; MEPS; GC-MS; LC-MS; Drug analysis; TANDEM MASS-SPECTROMETRY; HUMAN URINE SAMPLES; MOLECULARLY IMPRINTED POLYMER; LIQUID-CHROMATOGRAPHY; PLASMA SAMPLES; SYRINGE MEPS; ONLINE MICROEXTRACTION; LOCAL-ANESTHETICS; WASTE-WATER; LC;

D O I：

10.1016/j.aca.2011.05.037

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

This tutorial provides an overview on a new technique for sample preparation, microextraction by packed sorbent (MEPS). Not only the automation process by MEPS is the advantage but also the much smaller volumes of the samples, solvents and dead volumes in the system. Other significant advantages such as the speed and the simplicity of the sample preparation process are provided. In this tutorial the main concepts of MEPS will be elucidated. Different practical aspects in MEPS are addressed. The factors affecting MEPS performance will be discussed. The application of MEPS in clinical and pre-clinical studies for quantification of drugs and metabolites in blood, plasma and urine will be provided. A comparison between MEPS and other extraction techniques such as SPE, LLE, SPME and SBSE will be discussed. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：119 / 128

页数：10

相关论文

共 45 条

[1]

Microextraction in packed syringe online with liquid chromatography-tandem mass spectrometry: Molecularly imprinted polymer as packing material for MEPS in selective extraction of ropivacaine from plasma [J].

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Microextraction in packed syringe (MEPS) for liquid and gas chromatographic applications. Part II - Determination of ropivacaine and its metabolites in human plasma samples using MEPS with liquid chromatography/tandem mass spectrometry [J].

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JOURNAL OF MASS SPECTROMETRY, 2004, 39 (12) :1488-1493

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Abdel-Rehim, M .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 801 (02) :317-321

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MEPS as a rapid sample preparation method to handle unstable compounds in a complex matrix:: Determination of AZD3409 in plasma samples utilizing MEPS-LC-MS-MS [J].

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JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2007, 30 (20) :3029-3041

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JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2006, 29 (17) :2537-2544

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Quantification of 4-OH-2,6-xylidine and its conjugates in human urine samples utilising microextraction in packed syringe on-line with liquid chromatography and electrospray tandem mass spectrometry (MEPS-LC-MS/MS) [J].

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JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2006, 29 (16) :2413-2424

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Quantification of ropivacaine and its major metabolites in human urine samples utilizing microextraction in a packed syringe automated with liquid chromatography-tandem mass spectrometry (MEPS-LC-MS/MS) [J].

Abdel-Rehim, Mohamed ;

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JOURNAL OF SEPARATION SCIENCE, 2006, 29 (11) :1658-1661

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