Sumo, ubiquitin's mysterious cousin

被引：648

作者：

Müller, S ^{[1
]}

Hoege, C ^{[1
]}

Pyrowolakis, G ^{[1
]}

Jentsch, S ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 03期

关键词：

D O I：

10.1038/35056591

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.

引用

页码：202 / 210

页数：9

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