Efficient stereochemical relay en route to leucascandrolide A

被引：96

作者：

Kozmin, SA ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 05期

关键词：

D O I：

10.1021/ol015514x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A complete relay of the initial stereochemical information is central to the efficient and highly stereocontrolled construction of the C-1-C-15 fragment of the marine macrolide leucascandrolide A. Cyclic silane 3, assembled via Pt-catalyzed hydrosilylation, was designed to serve as a temporary template for the installation of the C-12 stereogenic center, The strategy features a highly convergent C-10-C-11 bond construction via 1,5-anti-selective aldol reaction and rapid assembly of the trisubstituted pyran subunit via Prins desymmetrization.

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页码：755 / 758

页数：4

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