BMP inhibition enhances axonal growth and functional recovery after spinal cord injury

被引：89

作者：

Matsuura, Iichiro ^{[2
,3
]}

Taniguchi, Junko ^{[2
]}

Hata, Katsuhiko ^{[1
,2
]}

Saeki, Naokatsu ^{[3
]}

Yamashita, Toshihide ^{[1
,2
]}

机构：

[1] Osaka Univ, Dept Mol Neurosci, Grad Sch Med, Osaka 5650871, Japan

[2] Chiba Univ, Dept Neurobiol, Grad Sch Med, Chou Ku, Chiba, Japan

[3] Chiba Univ, Dept Neurol Surg, Grad Sch Med, Chou Ku, Chiba, Japan

来源：

JOURNAL OF NEUROCHEMISTRY | 2008年 / 105卷 / 04期

关键词：

axon; bone morphogenetic proteins; neuron; regeneration; spinal cord;

D O I：

10.1111/j.1471-4159.2008.05251.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor-beta superfamily. BMPs regulate several crucial aspects of embryonic development and organogenesis. The reemergence of BMPs in the injured adult CNS suggests their involvement in the pathogenesis of the lesion. Here, we demonstrate that BMPs are potent inhibitors of axonal regeneration in the adult spinal cord. The expression of BMP-2/4 is elevated in oligodendrocytes and astrocytes around the injury site following spinal cord contusion. Intrathecal administration of noggin - a soluble BMP antagonist-leads to enhanced locomotor activity and reveals significant regrowth of the corticospinal tract after spinal cord contusion. Thus, BMPs play a role in inhibiting axonal regeneration and limiting functional recovery following injury to the CNS.

引用

页码：1471 / 1479

页数：9

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