BMP inhibits neurite growth by a mechanism dependent on LIM-kinase

被引：17

作者：

Matsuura, Iichiro

Endo, Mitsuharu

Hata, Katsuhiko

Kubo, Takekazu

Yamaguchi, Atsushi

Saeki, Naokatsu

Yamashita, Toshihide

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurobiol, Chou Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Neurol Surg, Chou Ku, Chiba 2608670, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 360卷 / 04期

关键词：

bone morphogenetic proteins; neurite; LIM-kinase; neurons; SPINAL-CORD-INJURY; RHO-KINASE; AXON REGENERATION; PROTEIN-KINASE; PHOSPHORYLATION; RECEPTOR; ACTIVATION; CELLS; IDENTIFICATION; EXPRESSION;

D O I：

10.1016/j.bbrc.2007.06.157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor-beta superfamily. BMPs regulate several crucial aspects of embryonic development and organogenesis. Here, we demonstrate that BMP-2 inhibits the neurite outgrowth of postnatal cerebellar neurons in vitro. Although receptor-regulated Smad proteins are activated by BMP-2, this signal transduction is not necessary for the inhibitory effect of BMP-2. Interestingly, BMP-2 activates LIM-kinase 1 in the neurons, and the dominant negative form of LIM-kinase I abolishes the effect of BMP-2. Thus, BMP-2 inhibits neurite outgrowth by a LIM-kinase 1-dependent mechanism, and our findings add a new member to the group of neurite growth inhibitors. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：868 / 873

页数：6

共 20 条

[1] Phosphorylation of collapsin response mediator protein-2 by Rho-kinase -: Evidence for two separate signaling pathways for growth cone collapse [J].