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The role of p53 in the immunobiology of cutaneous squamous cell carcinoma

被引：20
作者：
Black, APB [1 ]
Ogg, GS [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC,Human Immunol Unit, Oxford OX3 9DS, England
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2003年 / 132卷 / 03期
基金：
英国医学研究理事会;
关键词：
squamous cell carcinoma; p53; cytotoxic T lymphocytes; human papillomavirus;
D O I：
10.1046/j.1365-2249.2003.02159.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.
引用
收藏
页码：379 / 384
页数：6
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