The role of p53 in the immunobiology of cutaneous squamous cell carcinoma

被引：20

作者：

Black, APB ^{[1
]}

Ogg, GS ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC,Human Immunol Unit, Oxford OX3 9DS, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2003年 / 132卷 / 03期

基金：

英国医学研究理事会;

关键词：

squamous cell carcinoma; p53; cytotoxic T lymphocytes; human papillomavirus;

D O I：

10.1046/j.1365-2249.2003.02159.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.

引用

页码：379 / 384

页数：6

共 97 条

[81] Role of a p53 polymorphism in the development of human papillomavirus-associated cancer [J].

Storey, A ;

Thomas, M ;

Kalita, A ;

Harwood, C ;

Gardiol, D ;

Mantovani, F ;

Breuer, J ;

Leigh, IM ;

Matlashewski, G ;

Banks, L .

NATURE, 1998, 393 (6682) :229-234

[82] IDENTIFICATION OF WILD-TYPE AND MUTANT P53 PEPTIDES BINDING TO HLA-A2 ASSESSED BY A PEPTIDE LOADING-DEFICIENT CELL-LINE ASSAY AND A NOVEL MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I PEPTIDE BINDING ASSAY [J].

STUBER, G ;

LEDER, GH ;

STORKUS, WJ ;

LOTZE, MT ;

MODROW, S ;

SZEKELY, L ;

WOLF, H ;

KLEIN, E ;

KARRE, K ;

KLEIN, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (03) :765-768

[83] Targeting p53 as a general tumor antigen [J].

Theobald, M ;

Biggs, J ;

Dittmer, D ;

Levine, AJ ;

Sherman, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :11993-11997

[84] Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes [J].

Theobald, M ;

Biggs, J ;

Hernandez, J ;

Lustgarten, J ;

Labadie, C ;

Sherman, LA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (05) :833-841

[85] The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope [J].

Theobald, M ;

Ruppert, T ;

Kuckelkorn, U ;

Hernandez, J ;

Häussler, A ;

Ferreira, EA ;

Liewer, U ;

Biggs, J ;

Levine, AJ ;

Huber, C ;

Koszinowski, UH ;

Kloetzel, PM ;

Sherman, LA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (06) :1017-1028

[86]

Thomas M, 1999, MOL CELL BIOL, V19, P1092

[87] PRIMARY PROLIFERATIVE T-CELL RESPONSE TO WILD-TYPE P53 PROTEIN IN PATIENTS WITH BREAST-CANCER [J].

TILKIN, AF ;

LUBIN, R ;

SOUSSI, T ;

LAZAR, V ;

JANIN, N ;

MATHIEU, MC ;

LEFRERE, I ;

CARLU, C ;

ROY, M ;

KAYIBANDA, M ;

BELLET, D ;

GUILLET, JG ;

BRESSACDEPAILLERETS, B .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (06) :1765-1769

[88]

van der Burg SH, 2002, CLIN CANCER RES, V8, P1019

[89]

van der Burg SH, 2001, EUR J IMMUNOL, V31, P146, DOI 10.1002/1521-4141(200101)31:1<146::AID-IMMU146>3.0.CO

[90]

2-T

← 1 2 3 4 5 6 7 8 9 10 →