Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA

被引：40

作者：

McCue, KP ^{[1
]}

Voss, DA ^{[1
]}

Marks, C ^{[1
]}

Morrow, JR ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1998年 / 18期

关键词：

D O I：

10.1039/a805916k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The hydrolysis of the monoribonudeotide GpppG, a model compound for the 5'-cap structure of mRNA, by dinuclear Cu(rr) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second-order dependence on the catalyst was observed for two different dinuclear complexes.

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页码：2961 / 2963

页数：3

相关论文

共 39 条

[1]

[Anonymous], ANTISENSE RES APPL

[2] Decapitation of a 5' capped RNA by an antisense copper complex conjugate [J].

Baker, BF ;

Ramasamy, K ;

Kiely, J .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (14) :1647-1652

[3] DECAPITATION OF A 5'-CAPPED OLIGORIBONUCLEOTIDE BY O-PHENANTHROLINE-CU(II) [J].

BAKER, BF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (08) :3378-3379

[4] Cleavage of the 5' cap structure of mRNA by a europium(III) macrocyclic complex with pendant alcohol groups [J].

Baker, BF ;

Khalili, H ;

Wei, N ;

Morrow, JR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (38) :8749-8755

[5] SEQUENCE-SPECIFIC CLEAVAGE OF HIV MESSENGER-RNA BY A RIBOZYME MIMIC [J].

BASHKIN, JK ;

FROLOVA, EI ;

SAMPATH, US .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (13) :5981-5982

[6] PREPARATION AND CRYSTAL AND MOLECULAR-STRUCTURE OF DIBROMO(1,4,7-TRIAZACYCLONONANE)COPPER(II) [J].

BEREMAN, RD ;

CHURCHILL, MR ;

SCHABER, PM ;

WINKLER, ME .

INORGANIC CHEMISTRY, 1979, 18 (11) :3122-3125

[7] SELECTIVE HYDROLYSIS OF PHOSPHATE-ESTERS, NITROPHENYL PHOSPHATES AND UPU, BY DIMERIC ZINC-COMPLEXES DEPENDS ON THE SPACER LENGTH [J].

CHAPMAN, WH ;

BRESLOW, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (20) :5462-5469

[8] Mechanistic studies of dichloro(1,4,7-triazacyclononane)copper(II)-catalyzed phosphate diester hydrolysis [J].

Deal, KA ;

Burstyn, JN .

INORGANIC CHEMISTRY, 1996, 35 (10) :2792-2798

[9]

EPSTEIN DA, UNPUB

[10] Synthesis of a series of novel binucleating ligands based on 1,4,7-triazacyclononane and o-, m- and p-xylene: Crystal structure of the mu-hydroxy-bridged dicopper(II) complex [Cu(2)L(m)(OH)(2)][BPh(4)](2) [L(m) equals alpha,alpha'-bis(N-1,4,7-triazacyclononane)-m-xylene] [J].

Farrugia, LJ ;

Lovatt, PA ;

Peacock, RD .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1997, (06) :911-912

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