The acute effects of norharman on cocaine self-administration and sensorimotor function in male Wistar rats

The purpose of the present study was to determine the acute effects of the beta -carboline norharman on cocaine dependence. Male Wistar rats were allowed to self-administer cocaine for 3 h for seven sessions. A single injection of norharman (0.2-20 mg/kg, i.p.) was given 30 min before the onset of the seventh session. It was shown that norharman decreased the cocaine intake in a U-shaped manner with the dose of 10 mg/kg having the most potent effect. These results indicate that several receptor mechanisms mediate the effects of norharman. In addition, 15 min following the administration of norharman on session 7, motor and sensory skill tests were performed. Six naive animals were tested with the dose, which has the most pronounced effect on cocaine self-administration intake, in order to examine whether the observed effects were due to norharman or due to the combination of norharman and cocaine. It was observed that norharman in both the naive and cocaine-exposed animals significantly increased the response time in the somato-sensory orienting test. However, only in the naive animals a significant effect of norharman on the grasp reflex was observed. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.