Novel, potent and selective cyclin D1/CDK4 inhibitors:: Indolo[6,7-a]pyrrolo[3,4-c]carbazoles

被引：57

作者：

Engler, TA ^{[1
]}

Furness, K

Malhotra, S

Sanchez-Martinez, C

Shih, C

Xie, W

Zhu, GX

Zhou, X

Conner, S

Faul, MM

Sullivan, KA

Kolis, SP

Brooks, HB

Patel, B

Schultz, RM

DeHahn, TB

Kirmani, K

Spencer, CD

Watkins, SA

Considine, EL

Dempsey, JA

Ogg, CA

Stamm, NB

Anderson, BD

Campbell, RM

Vasudevan, V

Lytle, ML

机构：

[1] Eli Lilly & Co, Lilly Res Lab, Indianapolis, IN 46285 USA

[2] Lilly Spain SA, Madrid 28108, Spain

[3] Eli Lilly & Co, Chem Proc Res & Dev, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(03)00461-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2261 / 2267

页数：7

共 59 条

[11] Identification of selective inhibitors of cyclin dependent kinase 4 [J].

Carini, DJ ;

Kaltenbach, RF ;

Liu, J ;

Benfield, PA ;

Boylan, J ;

Boisclair, M ;

Brizuela, L ;

Burton, CR ;

Cox, S ;

Grafstrom, R ;

Harrison, BA ;

Harrison, K ;

Akamike, E ;

Markwalder, JA ;

Nakano, Y ;

Seitz, SP ;

Sharp, DM ;

Trainor, GL ;

Sielecki, TM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (16) :2209-2211

[12] Wnt signaling to β-catenin involves two interactive components -: Glycogen synthase kinase-3β inhibition and activation of protein kinase C [J].

Chen, RH ;

Ding, WV ;

McCormick, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17894-17899

[13] The B cell antigen receptor regulates the transcriptional activator β-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3 [J].

Christian, SL ;

Sims, PV ;

Gold, MR .

JOURNAL OF IMMUNOLOGY, 2002, 169 (02) :758-769

[14]

DARZYNKIEWICZ Z, 1997, CURRENT PROTOCOLS CY

[15] THE SYNTHESIS OF 7-ALKOXYINDOLES [J].

DOBSON, D ;

TODD, A ;

GILMORE, J .

SYNTHETIC COMMUNICATIONS, 1991, 21 (05) :611-617

[16] Cell cycle control and cancer [J].

Draetta, G ;

Pagano, M .

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 31, 1996, 31 :241-248

[17] Glycogen synthase kinase 3: an emerging therapeutic target [J].

Eldar-Finkelman, H .

TRENDS IN MOLECULAR MEDICINE, 2002, 8 (03) :126-132

[18] An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles [J].

Engler, TA ;

Furness, K ;

Malhotra, S ;

Diefenbacher, C ;

Clayton, JR .

TETRAHEDRON LETTERS, 2003, 44 (14) :2903-2905

[19] A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides [J].

Faul, MM ;

Winneroski, LL ;

Krumrich, CA .

TETRAHEDRON LETTERS, 1999, 40 (06) :1109-1112

[20] A new, efficient method for the synthesis of bisindolylmaleimides [J].

Faul, MM ;

Winneroski, LL ;

Krumrich, CA .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (17) :6053-6058

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