Carbon nanotubes for transdermal drug delivery

被引：50

作者：

Degim, Ismail Tuncer ^{[1
,2
]}

Burgess, Diane J. ^{[2
]}

Papadimitrakopoulos, Fotios ^{[3
]}

机构：

[1] Gazi Univ, Dept Pharmaceut Technol, Fac Pharm, TR-06330 Ankara, Turkey

[2] Univ Connecticut, Sch Pharm, Storrs, CT 06269 USA

[3] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA

来源：

JOURNAL OF MICROENCAPSULATION | 2010年 / 27卷 / 08期

关键词：

INDOMETHACIN; WATER; CELLS; SOLUBILIZATION; IONTOPHORESIS; PERMEABILITY; TRANSPORTERS; DOXORUBICIN; ABSORPTION; BEHAVIOR;

D O I：

10.3109/02652048.2010.506581

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this study, drug carrier properties through skin and penetration enhancement effects of carbon nanotubes (CNTs) are presented. Multi-walled and double-walled carbon nanotubes were used. Penetration enhancement into the skin following passive diffusion and iontophoresis were determined. Possible solubility enhancement effects and drug adsorption properties of CNTs were investigated. CNTs were found to be a useful drug carrier system and they can provide a high loading and enhanced transdermal penetration for especially hydrophobic drugs. The electroconductive nature of CNTs allows easy application of iontophoresis and the additional advantage of CNTs appears to be using them as electrodes.</.

引用

页码：669 / 681

页数：13

共 57 条

[1] ESTIMATION OF THE PORE-SIZE AND CHARGE-DENSITY IN HUMAN CADAVER SKIN [J].

AGUILELLA, V ;

KONTTURI, K ;

MURTOMAKI, L ;

RAMIREZ, P .

JOURNAL OF CONTROLLED RELEASE, 1994, 32 (03) :249-257

[2] Relationship between Polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs [J].

Alvarez-Núñez, FA ;

Yalkowsky, SH .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 200 (02) :217-222

[3]

AVDEEF A, 2007, Medicinal Chemistry, V5, P399

[4] Solubility of sparingly-soluble ionizable drugs [J].

Avdeef, Alex .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (07) :568-590

[5]

Banga AK, 1998, ELECT ASSISTED TRANS, P33

[6] Absorption classification of oral drugs based on molecular surface properties [J].

Bergström, CAS ;

Strafford, M ;

Lazorova, L ;

Avdeef, A ;

Luthman, K ;

Artursson, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (04) :558-570

[7] Applications of carbon nanotubes in drug delivery [J].

Bianco, A ;

Kostarelos, K ;

Prato, M .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (06) :674-679

[8] METHODS FOR INVITRO PERCUTANEOUS-ABSORPTION STUDIES .2. ANIMAL-MODELS FOR HUMAN-SKIN [J].

BRONAUGH, RL ;

STEWART, RF ;

CONGDON, ER .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 62 (03) :481-488

[9] Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing [J].

Cai, D ;

Mataraza, JM ;

Qin, ZH ;

Huang, ZP ;

Huang, JY ;

Chiles, TC ;

Carnahan, D ;

Kempa, K ;

Ren, ZF .

NATURE METHODS, 2005, 2 (06) :449-454

[10] Solid-state β-cyclodextrin complexes containing indomethacin, ammonia and water.: II.: Solubility studies [J].

Casella, R ;

Williams, DA ;

Jambhekar, SS .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 165 (01) :15-22

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