Hydroxyl end-capped macromers of N-vinyl-2-pyrrolidinone as precursors of amphiphilic block copolymers

被引:29
作者
Bartolozzi, Irene [1 ]
Solaro, Roberto [1 ]
Schacht, Etienne [2 ]
Chiellini, Emo [1 ]
机构
[1] Univ Pisa, Dept Chem & Ind Chem, INSTM UdR, Lab Bioact Polymer Mat Biomed & Environm Appl, I-56126 Pisa, Italy
[2] Univ Ghent, Dept Organ Chem, Polymer Chem & Biomat Res Grp, B-9000 Ghent, Belgium
关键词
functionalized PVP oligomers; ring opening polymerization; amphiphilic block copolymers; micelles;
D O I
10.1016/j.eurpolymj.2007.08.011
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Telechelic N-vinyl-2-pyrrolidinone (NVP) oligomers terminated by hydroxyl groups were prepared by radical polymerization in the presence of functional chain transfer agents. Then hydroxy-terminated poly(NVP) was used as initiator in the ring opening polymerization of epsilon-caprolactone (epsilon-CL). Experiments were performed either under basic conditions or by using SnOct(2) or ZnEt2 as catalyst. The resulting amphiphilic AB-type block copolymers were thoroughly characterized by spectroscopic and thermal techniques. These data and fractionation in protic solvents indicated that the copolymerization products are constituted by a mixture of copolymers with a wide composition range. The water-soluble copolymer fractions formed micelles and nanoaggregates that showed an appreciable capacity of loading piroxicam, a hydrophobic non-steroidal anti-inflammatory drug. Contact angle measurements, atomic force microscopy, and surface plasmon resonance measurements indicated that the surface of films prepared from the insoluble fractions does not have antiopsonizing properties in spite of their high hydrophilicity. (c) 2007 Published by Elsevier Ltd.
引用
收藏
页码:4628 / 4638
页数:11
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