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Cellular senescence in cancer and aging

被引：1329
作者：
Collado, Manuel [1 ]
Blasco, Maria A. [1 ]
Serrano, Manuel [1 ]
机构：
[1] CNIO, Spanish Natl Canc Res Ctr, Madrid, Spain
来源：
CELL | 2007年 / 130卷 / 02期
关键词：
D O I：
10.1016/j.cell.2007.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.
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收藏
页码：223 / 233
页数：11
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